Primary immunoglobulin repertoire development: time and space matter

Primary immunoglobulin repertoire development: time and space matter.

The primary immunoglobulin repertoire develops via opposing forces of expanding diversification balanced by contracting selection mechanisms. The resulting shape is essential for host health and immune fitness. While the molecular mechanisms of Ig diversification have largely been defined, selection forces shaping emerging Ig repertoires are poorly understood. During lifetime, human and mouse e...

VH replacement in primary immunoglobulin repertoire diversification.

The genes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (diversity), and J (joining) elements through a RAG-mediated recombination process that relies on the recognition of recombination signal sequences (RSSs) flanking the individual elements. Secondary V(D)J rearrangement modifies the original Ig rearrangement if a nonproductive original joint i...

Bovine B cells: B lymphopoiesis and the generation of primary immunoglobulin repertoire in fetal cattle

Space Economy and Rural Development

Despite all initiatives and endeavors, Iran’s rural communities are encountering with challenges regarding the achievement of comprehensive development. Space economy is associated with location distribution of economic activities as well as movement and flow of population, goods, services, and capital. These in turn, would have great impact upon the development level of different settlement in...

Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals.

The B-cell lineage, the antibodies produced by these cells and the diversification of the antibody repertoire are essential for the health and survival of all mammals. Cattle, sheep, swine and horses, unlike rodents and primates, develop their antibody repertoire from a relatively small number of VH (variable heavy) genes of one or several families and cattle, sheep and horses use almost exclus...